Claude Capdepon EMEA & South East Asia application laboratory manager at Rousselot explains how to avoid crosslinking in soft gel formulations.
PItfalls
The popularity of soft gel capsules continues to rise, with the latest market reports predicting a CAGR of 5.46% and a global market value of $3,276 million by 2023. Typically used to carry semi-solids, liquids, gels or paste-like fills, soft gels offer a versatile solution to active pharmaceutical (API) ingredient delivery.
Soft gel capsule design
When designing a soft gel formulation, shelf-life stability, shell dissolution, and formulation versatility must all be carefully considered. Consumer experience is also key – from taste and odour masking, to swallowability. As such, gelatin is the preferred excipient for soft gel applications, due to its robust functional properties, full digestibility, and compliance with stringent regulatory requirements. Plus, as the only clean label excipient, it provides added appeal for an increasing number of consumers.