Dr Hani El-Sabbahy, a biopharmaceutical application engineering specialist at science-based technology company 3M, outlines some of the challenges associated with continuous multicolumn protein A chromatography.
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The advantages of continuous bioprocessing have been well covered in the literature. They include reduced equipment footprint, reduced capital cost, higher productivity, greater flexibility to increase capacity by operating parallel production lines, and, in some respects, enable a steady state operation. There is, therefore, significant interest in continuous processing in the biopharmaceutical industry.1