In this article, Katharina Paulsen, Ines Ruff, Dirk Leister, Jennifer Ramirez and Robert Heintz from Thermo Fisher Scientific, describe a co-extrusion technique and how Raman imaging microscopy was used to measure the thickness, quality and continuity of the outer shell of the extruded material.
Imaging quality
Hot melt extrusion is a process used to produce a broad range of pharmaceutics. It can be used for oral applications, implants or patches. In oral solid dosage forms it can be either used to increase the bioavailability of poorly soluble active pharmaceutical ingredients (API) in immediate and sustained release formulations or even in combination of different release behaviours.1,2