Here Dr. Carmen Guguta, global head of business development and marketing at crystallisation technology provider, Technobis Crystallization Systems, explains how new technology is streamlining crystallisation research.
Key insights:
- Crystallisation research is necessary to find either the most thermodynamically stable form or the right polymorphic form of a drug in the development process.
- Understanding the solubility of the compound in different solvents is necessary for scientists to have more information about its polymorphic behaviour of the compound and how to design future solid state screening studies.
- New technology means scientists can perform up to 16 different crystallisation experiments on the same device, generating simple phase diagrams and solubility curves.
Crystallisation research plays a crucial role in drug development as more than 90 per cent of APIs are synthesised as a crystalline product. Traditionally, several challenges have interfered with scientists’ ability to deliver crystallisation research effectively.