David O’Connell, director of scientific affairs at PCI Pharma Services, discusses the principles of roller compaction – particularly in the development and manufacturing of oral solid dosage forms containing highly potent active pharmaceutical ingredients (API).
Roll
Granulation is a process in which primary powder particles adhere to each other, resulting in larger, multi-particle entities; ‘granules’. When performed without adding liquid binders, it is called dry granulation: the powder blend is compacted by applying a force, causing adhesion and size enlargement. The subsequent granules can be processed into tablets, capsules and powder in bottle/sachets.