The biopharmaceutical industry has made significant strides in optimising drug development and downstream production processes, with the use of chromatography columns critical for the purification of biopharmaceutical products.
However, conventional column packing can be a complex and challenging process, which can create production bottlenecks and may result in inconsistencies and errors. The quality and reproducibility of data and the product itself can also be affected, making it difficult to ensure that approved quality standards are consistently followed. In addition, the use of different resins from various suppliers further complicates the column packing process, as each supplier provides their own recommendations. This introduces an additional degree of variability that can lead to inconsistent results. If a column fails to meet the set qualifications and approval requirements, the packing process would need to be repeated, leading to delays and increased costs.