Doug Millington-Smith, principal applications specialist at powder characterisation company Freeman Technology, considers the value of multivariate powder characterisation as a solution to the demand for comprehensive data.
Pick of the bunch
Well-established techniques for material characterization may not provide the differentiation required to quantify variations in batches of excipients that contribute to variation in downstream process behaviour. A fundamental part of quality by design (QbD) is the need to establish a design space of acceptable raw material properties which requires understanding of a diverse range of excipient properties.