Traditionally, excipient selection has been performed using trial-and-error based methodologies, which are time-consuming and expensive. In this article, Dr Amjad Alhalaweh, PhD, formulation scientist, Recipharm, discusses a new method, high-throughput screening (HTS), which can help to tackle excipient selection challenges.
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Many companies are facing solubility challenges of new chemical entities (NCEs) during development processes. The solubility of a compound is fundamental in reaching the necessary concentration for the required pharmacological response.