Here, Pingyun (P.Y.) Chen, PhD, director of Early Development at Catalent Pharma Solutions, details some of the important considerations required in product development and how a holistic approach can help save money and time in the long run.
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Crystalline forms predominate in solid form screening, although more recently, the traditional salt and polymorphic forms have been supplemented by co-crystals and amorphous solid dispersions. The aim is to select the solid form with optimal solubility, stability and manufacturability, and balance those factors with cost and material availability to ensure projected timelines are met.