David O’Connell, director of Scientific Affairs at PCI Pharma Services looks at the ways in which pharmaceutical manufacturers can overcome challenges in potent compound granulation.
compounding
Pharmaceutical granulation is a common technique for solid oral drug production, whether as tablets, capsules or granules for use in bottles or sachets. Multiple granulation methodologies can be used to address the requirements of a wide range of Active Pharmaceutical Ingredients (API), irrespective of potency.
Granulation combines individual formulation components (API, diluents, binders, disintegrants) into a single uniform particle. The various techniques include wet granulation; dry granulation; fluid bed granulation; and hot melt granulation.