In this article, Jamie Clayton, operations director, Freeman Technology, considers the challenge of implementing continuous tablet production and evaluates dynamic powder characterisation as a technique to support the development of a continuous wet granulation process.
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Rising development costs, the requirement for faster times to market and the growth of generics production, have contributed to the need to improve efficiency across the pharmaceutical life cycle. Quality by design (QbD) and the application of process analytical technology (PAT) are driving progress, and smarter approaches to process development and operation, such as continuous manufacturing, are gaining momentum.