Jamie Clayton, operations director at Freeman Technology, explains how comprehensive, process relevant characterisation of wet granules can lead to control of tablet CQAs and assist design space definition in the manufacture of an OTC medicine.
Watch this design space
The adoption of a quality by design (QbD) approach to wet granulation requires manufacturers to fully understand the relationship between process variables — such as powder properties and equipment settings — and critical quality attributes (CQA) of the resulting product.